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KMID : 0361520040150030312
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Korean Journal of Psychopharmacology
2004 Volume.15 No. 3 p.312 ~ p.318
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Association between Clozapine-Induced Weight Gain and Serotonin 5-HT₂C Receptor Gene Polymorphism in Patients with Schizophrenia
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신동훈
김철민/김학중/정영인
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Abstract
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Objective: Weight gain is one of the troublesome adverse reaction to clozapine treatment. This problem can lead to poor adherence to treatment. Clozapine-induced weight gain may be associated with genetic predisposition. Recent studies have shown that a polymorphism of the promoter region of the serotonin 5-HTze receptor gene is associated with antipsychotic-induced weight gain. This study is to mvestigate the associatioo of clozapine-in-duced weight gain with-759CfT polymorphism of serotonin 5-HT2c receptor promoter gene in schizophrenic patIents. Methods: Fifty three patiems with schizophrenia were included in this study. The subjects were divided into two groups according to body weight change between the start and 10 weeks of clozapine. The cutoff level of weight change is 5% increase of initial body weight. Genotypes of-759OT polymorphism were. identified from Adi-digested fragments of two-primer products amplified by pol~´merase chain reaction corresponding to -885 to -634 of the serotonin 5-HT 2(´ receptor gene promoter region on chromosome X. Resuk.. : There were no differences of baseline ,´ariables between patient groups with and without weight gain. 4 of 32 male patients and 6 of 21 female patients had -7591´ allele, respectively- The authors found that patients with -759T allele had tendency to show less weight gain than those without this allele. Condusion : These findings suggest that do-zapine-induced weight gain mas be associated with genetic predisposition in schizophrenic patients. (Korean J PsychopharmacoI2004:15(3):312-318)
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